Event Title

CD82 Regulates TGF-Ꞵ Signaling in Metastatic Prostate Cell Lines

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Faculty Advisor: Dr. Suganthi Sridhar

Description

The metastasis suppressor CD82 and promoter CD151 are tetraspanins, a group of glycoproteins that collectively regulate various cellular processes, including cell differentiation, migration, adhesion, and signaling. These mechanisms are significant in nonpathological and pathological physiology; aberrant endothelial to mesenchymal transition permits cell migration and metastasis, and has been induced by TGF-β signaling. In renal cell carcinoma, CD151 has been shown to promote cell metastasis by activating TGF-β/SMAD signaling, whereas CD82 downregulates cell migration and invasion by inhibiting TGF-β/SMAD signaling. CD82 has been demonstrated to change CD151 surface expression and suppress invasion by regulating c-Met and Src signaling in metastatic prostate cell lines. The purpose of this experiment was to investigate if CD82’s and CD151’s abilities to respectively suppress and promote metastasis involve TGF-β signaling regulation in metastatic prostate cell lines.

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CD82 Regulates TGF-Ꞵ Signaling in Metastatic Prostate Cell Lines

The metastasis suppressor CD82 and promoter CD151 are tetraspanins, a group of glycoproteins that collectively regulate various cellular processes, including cell differentiation, migration, adhesion, and signaling. These mechanisms are significant in nonpathological and pathological physiology; aberrant endothelial to mesenchymal transition permits cell migration and metastasis, and has been induced by TGF-β signaling. In renal cell carcinoma, CD151 has been shown to promote cell metastasis by activating TGF-β/SMAD signaling, whereas CD82 downregulates cell migration and invasion by inhibiting TGF-β/SMAD signaling. CD82 has been demonstrated to change CD151 surface expression and suppress invasion by regulating c-Met and Src signaling in metastatic prostate cell lines. The purpose of this experiment was to investigate if CD82’s and CD151’s abilities to respectively suppress and promote metastasis involve TGF-β signaling regulation in metastatic prostate cell lines.

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